An introduction to the nicotine replacement therapy

Nicotine is well-known as being a drug of dependence, so it is theoretically possible for users to become dependent on medications that contain this agent, and for them to display signs of withdrawal upon cessation of use.

These products appear to be well tolerated. Contact:Email: moc.

nicotine replacement therapy guidelines

In terms of efficacy, a numerically higher abstinence rate was achieved with high-dose transdermal NRT. Controlled studies have demonstrated that, even in groups of smokers at high risk, the use of nicotine replacement products does not appear to significantly increase the likelihood of cardiovascular events, 22 and NRT has been found to be safe for use with hypertensive patients.

How does nicotine replacement therapy work

Shiffman S. The review aims to summarize literature on various modes of nicotine replacement therapy methods currently used to treat nicotine dependence, and to give an overview about future possible approaches to treat tobacco use disorder. Tob Control. The vapour inhaler was designed to satisfy behavioral aspects of smoking, namely, the hand-to-mouth ritual, while delivering nicotine to reduce physiological withdrawal symptoms produced by tobacco withdrawal. They provide general craving relief and breakthrough craving relief with immediate release of nicotine. Ferguson SG, Shiffman S. One might be tempted to conclude that the relationship between compliance and treatment outcome is noncausal. An important difference between NRT and cigarettes in this regard, however, is the speed at which peak blood levels of nicotine are achieved. Cue-provoked craving and nicotine replacement therapy in smoking cessation.

Perhaps most notably in terms of potential side effects of NRT use, nicotine administration has been shown to directly affect the cardiovascular system, increasing both heart rate and blood pressure.

Transdermal Patch is a slow sustained release form of nicotine delivery.

nicotine replacement therapy ppt

These NRTs are in general well tolerated and have minimal adverse effects. Pharmacol Biochem Behav. The range of dosages allows users to gradually decrease their nicotine intake over a period of several weeks or longer to enable a gradual adjustment of their bodies to lower nicotine levels and ultimately to a nicotine-free state.

Nicotine replacement therapy mechanism of action

Such products have also been found to be safe, with adverse events typically mild and transient, ceasing when treatment is stopped. Smoking Related Behaviour and Attitudes: N Engl J Med. J Subst Abuse Treat. There is no evidence that suggests use of other forms of NRT precessation is more effective than starting use on the quit day. Interventions to increase use of nicotine gum: a randomized, controlled, single-blind trial. Sadly, the literature is currently silent on effective strategies for improving compliance. The final safety concerns with NRT use that we will discuss here are the dependence potential of these medications, and, relatedly, the potential for withdrawal symptoms to manifest after stopping NRT use. However, the fact that compliance and adherence is generally poor even in clinical trials of NRT, where drug treatment is typically provided free of charge, would seem to contradict the notion that cost is a primary barrier to NRT compliance and adherence. Surveillance data from NRT sales data support this conclusion, suggesting that the vast majority of users do not maintain NRT use beyond the recommended therapeutic treatment duration. One study, however, that tried such an intervention with interested quitters was unsuccessful — providing brief education to gum users did not significantly change either the number of pieces of gum used per day, or the percentage of users who were categorized as compliant users. Lader D, Goddard E. Nicotine replacement therapy.
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Nicotine Replacement Therapy: An Overview